Organismal Form and Function Lab part of CUREnet:CURE Collection
Christopher Oufiero, Towson University
Invertebrates use movement of their bodies and structures in diverse ways to interact with their environment. This includes general locomotion (e.g., walking, jumping, flying) to specific forms of locomotion (e.g., gliding on water), using limbs to acquire food (e.g., raptorial forelegs in the praying mantis) and using structures to communicate (e.g., cricket calls). These movements have been the focus of bioinspiration studies to understand how these small organisms, with compact nervous systems, are able to achieve their movements. Given the diversity of invertebrates and the lack of information on the variation in their movements, the goals of this course are to understand the variation in invertebrate movement and explore the factors that may affect that variation. In this course, students have the opportunity to develop and test their own research hypotheses associated with variation in the movement of invertebrates. Using high-speed cameras, students are instructed on filming techniques to quantify animal movement, the use of the R programming language to obtain basic kinematics of movement and analyze their data, and the process of science from hypothesis formation to presentation of results. Research questions change each iteration based upon the hypotheses students develop, but the same instructional material and skillsets (e.g., quantifying animal movement) are consistently used. Results from each student group are presented during a departmental wide poster symposium and can be written up for publication, where applicable.

Genome Solver: Microbial Comparative Genomics part of CUREnet:CURE Collection
Gaurav Arora, Gallaudet University
Genome Solver began in 2011 as way to teach Bioinformatics tools to undergraduate faculty. As part of the Genome Solver project as a whole, we developed a Community Science Project (CSP) for faculty and students to join. The CSP explores horizontal gene transfer (HGT) between bacteria and the phages that infect them. Students get involved in this project and develop testable hypotheses about the role HGT between bacteria and phages play in microbial evolution. Our own work has demonstrated that undergraduates can produce publishable data using this approach. We invite faculty and their students to participate in the search for additional evidence of this type of HGT by investigating the vast wealth of phage and bacterial sequences currently in databases. All that is needed is a computer, an Internet connection, and enthusiasm for research. Faculty and students can work on an organism of interest or we can help them pick organisms to explore these phenomena. By pooling all of the information from a variety of small projects under the umbrella of the Genome Solver CSP, we will be able to better understand the role of HGT in bacterial evolution.

Using the CRISPR-Cas9 genome engineering technology to understand gene function in the zebrafish part of CUREnet:CURE Collection
Anil Kumar Challa, University of Alabama at Birmingham
Using a combination of bioinformatics and lab bench ('wet lab') tools, students design, synthesize and analyze CRISPR reagents that can effectively target specific sites in the genome. We use the zebrafish as a model system to understand gene function.