Molecular Parasitology
Swati Agrawal, University of Mary Washington
In Spring 2021, we piloted a mini-CURE where student groups from University of Mary Washington and Georgia State University collaboratively completed research projects as part of a research-intensive course on Molecular Parasitology. The benefits of this approach were immediately obvious as students interacted across institutions, learned from each other's disciplinary expertise while informing their own research with data collected by their collaborators.

Data Representation in MATLAB: From Raw Data to Insight
Ray Senior, University of Technology, Jamaica
This activity is a hands-on computational lab where students import, validate, inspect, and visualize three heterogeneous data types (spreadsheets, audio, images) to discover MATLAB's unified array-based data ...

Control Systems using Simulink
Kelvin Loutan, The University of Trinidad and Tobago
Analytically solving differential equations representing dynamic systems can sometimes distract from the physical implications of the model. In this module, the dynamic equations of a DC motor are used as a ...

ERP Peak Detective: Introduction to Event-Related Potential Analysis with MATLAB
Brian Rivera, St Olaf College
This scaffolded laboratory activity introduces students with minimal programming experience to Event-Related Potential (ERP) analysis using MATLAB. Students progress from interactive visual exploration of neural ...

Measuring voting districts and distributions
Eugene Mahmoud, Mt San Antonio College
This project-based activity allows students to use MATLAB to analyze voting district boundaries and their relationship to social and environmental justice. Students recreate geographic borders, calculate centroids, ...

Analysis of the effects of protein-protein interactions on signaling through a team-based undergraduate biochemistry laboratory course
Daniela Fera, Swarthmore College
We developed a research-based laboratory course centered on a biological problem involving the B-Raf kinase, specifically the mutant that is commonly found in melanomas. One of the major goals of the project for the students is to generate mutants to determine whether a particular region of the B-Raf protein is critical for the interaction with MEK kinase, a downstream target in the pathway. Students analyze the published B-Raf-MEK crystal structure and choose a mutation to generate in B-Raf or MEK that might alter the dissociation constant (KD) of the complex. They design primers, perform PCR to generate their desired mutant, transform and purify the resulting DNA, express the DNA in E. coli, and purify the protein, all before characterizing it. Characterizing the mutant proteins consist of performing basic pull-downs, western blots, spectroscopic absorbance assays, and biolayer interferometry for binding kinetics. Students also engage in group meeting presentations and journal clubs in which they discuss their work and related primary literature, respectively. Group meeting and journal club discussions provide a forum for students to come up with new ideas to analyze their results, or for future work. Students summarize key results in a final presentation and paper, and develop a research proposal based on their work. Data that students obtain from their mutants provide evidence of the importance of a binding region for B-Raf-MEK complex formation, as well as downstream phosphorylation events. Such data will inform future drug discovery programs, as well as form the foundation for students' work in the course the following year. Because working with mutants can result in unpredictable data and results, students sometimes have to adjust their protocols and repeat experiments. Thus, the CURE format of this course also gives students an opportunity to learn to troubleshoot when things do not work as expected, which helps them learn resiliency in science.

Virtual Geologic Mapping Exercise at Lough Fee
Steve Whitmeyer, James Madison University
The Virtual Geologic Mapping Exercise is designed to simulate an introductory field mapping exercise. Students load a KML file in Google Earth that includes real outcrop data in the form of dots and orientation ...

Stress Map
James Conder, Southern Illinois University-Carbondale
Use earthquakes from the global CMT catalog to look at crustal stresses in a given region of the Earth. Students will download earthquake data from an online catalog and make 2 tectonic maps. One map is of the ...

Discover Plate Tectonics
Angela Daneshmand, Santiago Canyon College
This is a student-centered activity for a synchronous online course where students access google slides to complete during a video conferencing session (eg. Zoom) in break out rooms. Students will be introduced to ...

Getting started with Structure from Motion (SfM) photogrammetry
Beth Pratt-Sitaula, EarthScope
Structure from Motion (SfM) photogrammetry method uses overlapping images to create a 3D point cloud of an object or landscape. It can be applied to everything from fault scarps to landslides to topography. This ...