Recently, the abundance of microplastics represent a major environmental concern. Microplastics are ubiquitous because of the gradual dumping of plastic wastes, inadequate standard detection methods, and their slow disposal rates. This research aimed at developing an innovative approach to remove microplastics from water via magnetite nanoparticles. Magnetite nanoparticles were synthesized using an aqueous solution of ferric and ferrous chloride as the precursors and ammonium hydroxide solution as the precipitation agent through a co-precipitation method. To confirm the presence of the magnetic nanoparticles, synthesized magnetite nanoparticles were characterized using two different techniques: Fourier transform infrared spectroscopy (FTIR) and transmission electron microscope (TEM). The response of magnetite nanoparticles to external magnet was investigated. With this removal approach, polystyrene microparticles were recovered. Overall, the procedure is efficient for various types of microplastics and can be used as a step of an extraction procedure for microplastics in water.