Design2Data
Ashley Vater, University of California-Davis
The D2D program is centered around an undergraduate-friendly protocol workflow that follows the design-build-test-learn engineering framework. This protocol has served as the scaffold for a successful undergraduate training program and has been further developed into courses that range from a 10-week freshman seminar to a year-long, upper-division molecular biology course. The overarching research goal of this CURE probes the current predictive limitations of protein-modeling software by functionally characterizing single amino acid mutants in a robust model system. The most interesting outcomes of this project are dependent on large datasets, and, as such, the project is optimal for multi-institutional collaborations.

Laser spectroscopy of atmospherically relevant molecules and clusters in helium nanodroplets
Paul Raston, James Madison University
Superfluid helium nanodroplets present an ideal medium for the study of chemical dynamics at the molecular level. Their low temperature, enormous heat conductivity, and weakly interacting nature allow for the investigation of various things, such as how molecular rotation is effected by a solvent, and how molecules interact with each other. These two topics will be addressed in the lab by (1) measuring the spectra of unexplored molecules in helium nanodroplets and determining their rotational constants; this data will then be used to test known models describing the interaction between the molecule and helium solvent, and (2) synthesizing and characterizing unexplored molecular clusters in an effort to better understand molecular solvation; students will solvate the "unexplored molecule" with an atmospherically relevant species (O2, N2, H2O), and investigate the resulting clusters with laser Stark spectroscopy.

Water in Gen Chem
Ruthanne Paradise, University of Massachusetts-Amherst

Investigating local climate change impacts in a STEM first year learning community
Mara Brady, California State University-Fresno
still in progress...

Polymer/Materials Structure-Property Relationship Investigations for General Chemistry Students
Zuleikha Kurji, Saint Marys College of California

Kinetics of bioorthogonal reactions
Jen Heemstra, Emory University
Bioorthogonal reactions such as strain-promoted azide-alkyne cycloaddition (SPAAC) and inverse electron demand Diels–Alder (IEDDA) are widely used for labeling of biomolecules, which in turn enables numerous applications in basic science and biotechnology. The key characteristic of these reactions is the ability of the functional groups involved to react with each other while remaining inert to the other functional groups found in nature. Despite the wide use of these chemistries, relatively few studies have evaluated the effect of reaction conditions on the kinetics of the reaction, and it would be of value to the scientific community to know how factors such as buffer identity, pH, ionic strength, and temperature impact reaction rate. In this CURE, students synthesize reagents or biomolecules and utilize UV spectrophotometry to measure the reaction rate under varying conditions. Students communicate their results in a final report written in the format of a peer-reviewed publication, and this CURE has yielded peer-reviewed research publications to share the data with the scientific community.

A short medicinal-chemistry inspired laboratory sequence aimed at understanding and controlling bacterial communication.
Laura Brown, Indiana University-Bloomington
Medicinal chemists are organic chemists (often employed by pharmaceutical companies) who synthesize and develop new organic molecules with favorable biological properties. As an illustrative example, penicillin was discovered in 1928 and developed into a drug in 1942. Resistance quickly arose and continues to be a problem, and penicillin is not effective against all types of bacteria. In the decades that followed, medicinal chemists synthesized a variety of molecules that were similar in structure to penicillin, but that either demonstrated enhanced antibiotic activity or did not exhibit the same resistance profile. A new approach to controlling the pathogenicity of bacteria is to simply "trick" the bacteria into remaining in their "normal" non-pathogenic state by controlling the ability of bacteria to communicate with one another by a mechanism termed "Quorum Sensing." Quorum sensing is a form of chemical communication by which bacteria sense each other's presence via concentration gradients of small molecules. I have a collaborator in the biology department who has developed a biochemical assay to identify inhibitors of this process, and the students who sign up for this course will synthesize a small library of molecules to test in this assay.

Chemical Analysis of Coffee Beans in Collaboration with a Local Roaster
Susan Oxley, St. Marys University
This CURE will take place in an Analytical Chemistry course. Students in the CURE course will collaborate with a local coffee roaster to develop a research question related to quantifying components of coffee beans. Using standard methods of analysis, students will work in groups to perform the analysis and validate their results. The outcome of the research will be a report to the coffee roaster.

Integration of a nanoparticles-based biosensing assay into a capillary column
Swarnapali Indrasekara, University of North Carolina at Charlotte
In this CURE project, junior and senior level chemistry students will be introduced to nanochemistry and its application in interdisciplinary research. Students will learn the use of chemistry concepts they have already learnt and also new spectroscopy and physical chemistry concepts. They will use that knowledge to develop an optical biosensor using nanoparticles in a capillary column as a potential point-of-care assay format.

What's in your water?
Robin Cotter, Phoenix College
Water quality is an issue that impacts everyone, but do we really know what is in the water we drink? Water quality is an issue that impacts everyone, but do we really know what is the water we drink? Chemical and bacteriological contamination of water has serious implications for human health. For example, in agricultural areas, pesticides and fertilizers can lead to contamination of groundwater. High levels of nitrate can lead to methaemoglobinaemia (blue baby syndrome). Solvents and heavy metals generated during mining can lead to toxicosis. As witnessed in Flint, Michigan, the use of lead pipes in plumbing can lead to elevated levels of lead in drinking water which can impact the mental development in children. Perfluorooctanoic acid (PFOA or C8) is a man-made chemical used in the process of making Teflon. PFOA's pose global health concerns as they persist in the environment and human body for extended periods of time and can now be detected in almost everyone's blood. To address this issue, introductory biology, microbiology and chemistry students at our 2-year community college will work together to test water from local water treatment plants for the presence of chemical and biological contaminants. Students will learn about the scientific process as they perform background research on EPA water standards, potential sources of water contaminants, and the water treatment process. Students will hold virtual meetings with community, university, and industry partners to identify relevant research questions related to water treatment. Students will then do a site visit to a local water treatment plant where they will collect and analyze water samples from different stages of the water treatment process. Students will test the water samples for the presence of organic pollutants and microbial pathogens. This data will be entered into a regional database and compared to water quality reports posted on the Arizona Department of Environmental Quality (ADEQ) website. Students will then present their findings at community meetings, STEM outreach events, and via virtual poster sessions.