CURE Examples



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Science Education Research for Pre-Service Elementary School Teachers
Dermot Donnelly, California State University-Fresno
This CURE focuses on supporting pre-service elementary school teachers to investigate predictors of peers' intentions to teach science in their future practice.

Discipline: Chemistry, Physics
State: California
Target Audience: Introductory
CURE Duration: A full term

Determining the Calcium and Magnesium Ions in Water (Total Water Hardness)
Candice Cortney, California State University-Fresno
CHEM 1AL is laboratory course that introduces laboratory methods in general chemistry for undergraduates who have declared, or interested in, a science major. The CURE research for this laboratory will be centered around students determining the total hardness of water from different sources of water (i.e. bottled, filtered, tap). This CURE design will span across seven consecutive weeks and this will allow students to plan, propose, implement, analyze, and present their results. Implementing a CURE design into this course will give students experience with research and reinforce proper laboratory techniques.

Discipline: Chemistry, Environmental Science:Water Quality and Quantity, Environmental Science, Chemistry:Analytical Chemistry, Environmental Chemistry
State: California
Target Audience: Introductory
CURE Duration: A few class periods

Yeast, metabolism and suicide: a brewing introduction to biochemical research
Laurent Dejean, California State University-Fresno
This course provides the student with a range of techniques and methodology appropriate to the study or phenomena at the biochemical, cellular, and organismic levels. In the spirit of genuine undergraduate research (CURE), the students will be involved directly in research that is ongoing in the Dejean's lab, i.e. the study of the mechanisms used by Bcl-2 family proteins to cross-regulate cell death and energy metabolism. The students' involvement in this type of research will be following a set of preliminary experiments which are aimed at familiarizing the students with common biochemistry lab skills; and with the manipulation of the yeast Saccharomyces cerevisiae which is to be used as the main model system in their research. Finally, the students will also engage directly with primary literature sources in preparation of their lab reports and an eventual presentation of their research at the Fresno State CURE symposium at the end of the semester.

Discipline: Chemistry:Biochemistry, Life Sciences:Cell Biology, Microbiology, Molecular Biology
Core Competencies: Analyzing and interpreting data, Developing and using models, Planning and carrying out investigations
Nature of Research: Basic Research, Wet Lab/Bench Research
State: California
Target Audience: Major, Upper Division

Fruit Flies as a Model of Human Neurodegenerative Disease
Joy Goto, California State University-Fresno
Upper-division biochemistry and chemistry majors will learn and iteratively apply the techniques of protein purification, DNA and protein gels, Western blot, DNA isolation, transformation, enzyme characterization to research the utility of fruit fly (D. melanogaster) to model the human neurodegenerative disease (e.g. ALS - Lou Gehrig's, Parkinson's Disease, Alzheimer's Disease).

Discipline: Chemistry, Biochemistry
Nature of Research: Wet Lab/Bench Research, Applied Research
State: California
Target Audience: Major

Polymer/Materials Structure-Property Relationship Investigations for General Chemistry Students
Zuleikha Kurji, Saint Marys College of California

Discipline: Chemistry, Organic Chemistry, Physical Chemistry
Core Competencies: Analyzing and interpreting data, Constructing explanations (for science) and designing solutions (for engineering), Planning and carrying out investigations, Asking questions (for science) and defining problems (for engineering)
Nature of Research: Wet Lab/Bench Research, Applied Research
State: California
Target Audience: Introductory, Non-major, Major
CURE Duration: A few class periods, Half a term

Course-Based Undergraduate Research Experience Lab: Design, Synthesis and Biological Evaluation of New Therapeutics in Pain Management
Stevan Pecic, California State University-Fullerton
This course will introduce students to the medicinal chemistry research experience. In this project, students will focus on in silico and structure-activity relationship (SAR) studies of small molecules designed to increase the levels of anti-inflammatory and antinociceptive endocannabinoids by inhibiting the enzyme Fatty Acid Amide Hydrolase (FAAH) responsible for their metabolism and degradation. Endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), are endogenous lipids that bind to and activate cannabinoid receptors. Activation of these receptors produces anti-inflammatory and analgesic effects. FAAH is a membrane enzyme that hydrolases endocannabinoids, thus inhibition of FAAH represents an attractive approach to develop new therapeutics for treating inflammation and pain.

Discipline: Chemistry, Biochemistry, Organic Chemistry
State: California
Target Audience: Major
CURE Duration: A full term

Visualizing protein aggregates involved in human disease
Whitney Duim, University of California-Davis

Discipline: Chemistry:Physical Chemistry, Chemistry, Life Sciences:Cell Biology, Physics:Optics, Chemistry:Biochemistry
Core Competencies: Analyzing and interpreting data, Constructing explanations (for science) and designing solutions (for engineering), Asking questions (for science) and defining problems (for engineering), Planning and carrying out investigations, Using mathematics and computational thinking
Nature of Research: Basic Research, Wet Lab/Bench Research
State: California
Target Audience: Introductory
CURE Duration: A full term

TRANSFER STUDENT CURE: Multi-organismal genomic analysis of molecular determinants of protein assembly.
Dylan Murray, University of California-Davis

Discipline: Chemistry, Biochemistry, Life Sciences:Cell Biology, Molecular Biology, Life Sciences, Plant Biology, Genetics, Chemistry:Physical Chemistry
Core Competencies: Analyzing and interpreting data, Planning and carrying out investigations
Nature of Research: Basic Research
State: California
Target Audience: Introductory
CURE Duration: Multiple terms

Probe the Effect of Physical Graphene Hole Morphology on its Acidity
Michael Groves, California State University-Fullerton
The purpose of this activity is to create and submit a job to a scheduler on a high-performance computing resource and conclude if the job relaxed to below a given threshold. We will also test how changing the requested resources affects the time to complete the job.

Discipline: Chemistry:Physical Chemistry, Chemistry
Core Competencies: Using mathematics and computational thinking
Nature of Research: Basic Research
State: California
Target Audience: Major