CURE Examples



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Chemistry
North Carolina

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Integration of a nanoparticles-based biosensing assay into a capillary column
Swarnapali Indrasekara, University of North Carolina at Charlotte
In this CURE project, junior and senior level chemistry students will be introduced to nanochemistry and its application in interdisciplinary research. Students will learn the use of chemistry concepts they have already learnt and also new spectroscopy and physical chemistry concepts. They will use that knowledge to develop an optical biosensor using nanoparticles in a capillary column as a potential point-of-care assay format.

Discipline: Chemistry:Analytical Chemistry, Engineering, Chemistry
Core Competencies: Analyzing and interpreting data, Planning and carrying out investigations, Asking questions (for science) and defining problems (for engineering)
Nature of Research: Applied Research, Wet Lab/Bench Research
State: North Carolina
Target Audience: Major, Upper Division

Understanding Noncovalent Interactions and Binding through PRRSM
Amanda Hargrove, Duke University
This CURE was designed to increase instruction on noncovalent interactions and intermolecular forces, provide laboratory experiences in biochemistry and chemical biology, and deliver a more consistent chemistry research experience to undergraduates at Duke University while staying within the existing curriculum. First, the concept of noncovalent interactions is visualized in an applied setting by examining 3D structures of small molecule:RNA interactions through a portable virtual reality (VR) environment. Next, using knowledge gained in the Hargrove lab regarding small molecule:RNA interactions along with the literature examples, teams of students evaluate known small molecule:RNA interactions, pose original scientific questions, and design a hypothesis-driven experiment that can be readily tested with commercially available materials using a standard fluorimeter or plate reader. These experiments directly contribute to research that examines patterns in the recognition of RNA structure by small molecules, and the students are able to assess their contribution to this ongoing interdisciplinary project.

Discipline: Chemistry:Organic Chemistry, Physical Chemistry, Biochemistry, Analytical Chemistry
Core Competencies: Analyzing and interpreting data, Using mathematics and computational thinking, Planning and carrying out investigations, Constructing explanations (for science) and designing solutions (for engineering), Asking questions (for science) and defining problems (for engineering)
Nature of Research: Basic Research, Wet Lab/Bench Research
State: North Carolina
Target Audience: Major, Upper Division
CURE Duration: Half a term

Animal Genome to Phenome - A CURE for food security
Mulumebet Worku, North Carolina A & T State University

Discipline: Chemistry:Biochemistry, Life Sciences:Cell Biology, Genetics, Life Sciences, Molecular Biology
Core Competencies: Developing and using models, Analyzing and interpreting data, Asking questions (for science) and defining problems (for engineering), Using mathematics and computational thinking
Nature of Research: Informatics/Computational Research, Basic Research, Applied Research
State: North Carolina
Target Audience: Major, Introductory
CURE Duration: Multiple terms