CURE Examples

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Chemistry

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Molecular Parasitology
Paul Ulrich, Georgia State University
Of the approximately 1000 different proteins that populate eukaryotic mitochondria, ~50% have no known function. Molecular Parasitology is a course-based intensively engages undergraduates by investigating roles of uncharacterized, mitochondrial proteins in trypanosomatid parasites. Students utilize basic bioinformatics (subcellular localization, conserved domain prediction, BLAST, secondary structure) to predict protein function followed by construction and transfection of GFP-fusion constructs into cell lines to validate their predictions. The CURE is designed to encourage independent problem-solving, science identity, and support career success.

Discipline: Life Sciences:Cell Biology, Health Sciences, Chemistry:Biochemistry, Life Sciences:Microbiology, Molecular Biology, Life Sciences
Core Competencies: Asking questions (for science) and defining problems (for engineering), Using mathematics and computational thinking, Planning and carrying out investigations, Analyzing and interpreting data
Nature of Research: Basic Research, Informatics/Computational Research
State: Georgia
Target Audience: Upper Division, Major
CURE Duration: A full term

Inhibitors for Malate Dehydrogenase
Dawn Marin, Gaston College
The goal of this CURE is to design, synthesize and test inhibitors of Malate Dehydrogenase. Students will study the structure of the enzyme and propose possible inhibitors that could form intermolecular bonds with the enzyme. Students will choose potential inhibitor molecules that can be purchased or easily synthesized and purified. The binding of inhibitors will be screened using computational docking calculations. Successful Inhibitors will be tested using enzymatic assays.

Discipline: Chemistry, Biochemistry
Core Competencies: Analyzing and interpreting data, Asking questions (for science) and defining problems (for engineering)
Nature of Research: Basic Research
State: North Carolina
Target Audience: Non-major, Introductory
CURE Duration: A few class periods

Bioenergy Materials for Renewable Energy: A Theoretical and Experimental Approach
Jalaal Hayes, Delaware State University
This course-based undergraduate research experience (CURE) will focus on the topic of biomass energy.

Discipline: Environmental Science:Sustainability, Chemistry:Physical Chemistry, Environmental Science:Energy
Core Competencies: Analyzing and interpreting data
CURE Duration: Half a term