CURE Examples
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CURE DurationA few class periods
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Inhibitors for Malate Dehydrogenase
Dawn Marin, Gaston College
The goal of this CURE is to design, synthesize and test inhibitors of Malate Dehydrogenase. Students will study the structure of the enzyme and propose possible inhibitors that could form intermolecular bonds with the enzyme. Students will choose potential inhibitor molecules that can be purchased or easily synthesized and purified. The binding of inhibitors will be screened using computational docking calculations. Successful Inhibitors will be tested using enzymatic assays.
Discipline: Chemistry, Biochemistry
Core Competencies: Analyzing and interpreting data, Asking questions (for science) and defining problems (for engineering)
Nature of Research: Basic Research
State: North Carolina
Target Audience: Non-major, Introductory
CURE Duration: A few class periods
Core Competencies: Analyzing and interpreting data, Asking questions (for science) and defining problems (for engineering)
Nature of Research: Basic Research
State: North Carolina
Target Audience: Non-major, Introductory
CURE Duration: A few class periods