CURE Collection

Browse through the collection of CUREs that have been submitted by community members. You can use the faceted search at the right to narrow the view of the collection. You can also use the free text search at any time.Contribute a CURE to the Collection »


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Results 1 - 10 of 19 matches

Exploring the Structure-Function Relationship in RNA Biochemistry

Discipline: Life Sciences:Molecular Biology, Chemistry:Biochemistry
Core Competencies: Planning and carrying out investigations, Constructing explanations (for science) and designing solutions (for engineering), Developing and using models, Analyzing and interpreting data, Using mathematics and computational thinking, Asking questions (for science) and defining problems (for engineering)
Nature of Research: Basic Research
State: Colorado
Target Audience: Upper Division, Major
CURE Duration: Half a term

Get the Lead Out: Impacts of Toxins from SuperFund Sites on Human Health, Ecology, and Socioeconomic Conditions, with an Evaluation of Environmental Racism in Regional Communities
Jessica Smith-Rohrberg, Massachusetts Bay Community College
Students in a community-college introductory Environmental Studies course will extract soil samples from a Massachusetts-based SuperFund site. They will analyze toxins and perform research to enhance and promote scientific literacy, to examine impacts of environmental toxins on human health and development, and to discuss equity and environmental racism.

Characterising the prokaryotic ATPase-ome
Alice Robson, University of Bristol
Students work in teams of 3-4 trying to identify and characterise putative ATPase enzymes from prokaryotic organisms. Each student identifies a putative uncharacterised ATPase gene from a range of prokaryotes (archaea and bacteria), and uses bioinformatic methods to characterise the gene. They then work in teams in the lab to clone, express and purify their chosen proteins; finally they characterise the protein using spectrophotometric ATPase assays. The team presents a poster on their work, then each student individually writes a report in the style of a short paper. The student grade is based on three assessed pieces: the lab book (20%), poster presentation (10%, graded as a team), and the report (70%). This course is compulsory for year 3 of our MSci Biochemistry programme, and counts for 20 credit points (out of 120 for the year). The course has been running since 2017 with an intake of 20-30 students per year, all of whom have passed the course.

Discipline: Life Sciences:Microbiology, Chemistry:Biochemistry, Life Sciences:Molecular Biology, Life Sciences
Core Competencies: Planning and carrying out investigations, Constructing explanations (for science) and designing solutions (for engineering), Analyzing and interpreting data, Asking questions (for science) and defining problems (for engineering)
Nature of Research: Basic Research, Informatics/Computational Research, Wet Lab/Bench Research
Target Audience: Major, Upper Division
CURE Duration: A full term, Multiple terms

BASIL (Biochemistry Authentic Scientific Inquiry Laboratory)
Arthur Sikora, Nova Southeastern University
This curriculum from the BASIL (Biochemistry Authentic Scientific Inquiry Laboratory) biochemistry consortium aims to get students to transition from thinking like students to thinking like scientists. Students will analyze proteins with known structure but unknown function using computational analyses and wet-lab techniques. BASIL is designed for undergraduate biochemistry lab courses, but can be adapted to first year (or even high school) settings, as well as upper-level undergraduate or graduate coursework. It is targeted to students in biology, biochemistry, chemistry, or related majors. Further details about the BASIL biochemistry consortium can be found on the BASIL blog, http://basiliuse.blogspot.com/ The curriculum is flexible and can be adapted to match the available facilities, the strengths of the instructor and the learning goals of a course and institution. These lessons are often used as part of upper-level laboratory coursework with at least one semester of biochemistry as a pre-requisite or co-requisite. The lab has been designed for classes ranging from 10-24 students (working in teams of two or three) per lab section. This lesson can be adapted to laboratory courses for introductory biology, cell and molecular biology, or advanced biology labs.

Discipline: Life Sciences:Molecular Biology, Computer Science, Chemistry:Biochemistry
Nature of Research: Wet Lab/Bench Research, Basic Research, Informatics/Computational Research
State: New York
Target Audience: Major, Upper Division
CURE Duration: Multiple terms, A full term

Genome to phenome: DNA-protein interactions involved in butterfly wing colored development
Michelle Borrero, University of Puerto Rico
We are interested in understanding the genomic mechanisms underlying morphological differences within species. We will use the wing color pattern of Heliconius erato as a model. We have developed a Course-based undergraduate research experience (CURE) that will engage undergraduate biology majors in the identification and purification of transcription factors in butterfly wing development. Through this experience students will be able to use the knowledge and concepts from the literature to make and defend decisions, explain the role of DNA binding proteins in the genome to phenome relationship and recognize the application and utility of the techniques used in the research for their career development.

Discipline: Life Sciences:Cell Biology, Genetics, Molecular Biology, Life Sciences, Evolution
Core Competencies: Analyzing and interpreting data, Asking questions (for science) and defining problems (for engineering), Planning and carrying out investigations
Nature of Research: Basic Research
Target Audience: Major
CURE Duration: A full term

Using the CRISPR-Cas9 genome engineering technology to understand gene function in the zebrafish
Anil Kumar Challa, University of Alabama at Birmingham
Using a combination of bioinformatics and lab bench ('wet lab') tools, students design, synthesize and analyze CRISPR reagents that can effectively target specific sites in the genome. We use the zebrafish as a model system to understand gene function.

Discipline: Life Sciences:Cell Biology, Molecular Biology, Genetics, Evolution
Core Competencies: Planning and carrying out investigations, Constructing explanations (for science) and designing solutions (for engineering), Using mathematics and computational thinking, Analyzing and interpreting data, Developing and using models, Asking questions (for science) and defining problems (for engineering)
State: Alabama
CURE Duration: A full term

A Bioinformatic Look at Iron Uptake in Insects
Emily Ragan, Metropolitan State University of Denver
Students will perform BLAST searches, make phylogenetic trees, identify putative orthologs, and investigate secondary structure elements of 5' untranslated regions (UTRs). The sequences used will be related to iron uptake in insects.

Discipline: Chemistry:Biochemistry, Life Sciences:Molecular Biology
Core Competencies: Analyzing and interpreting data
Nature of Research: Informatics/Computational Research
State: Colorado
Target Audience: Major, Upper Division
CURE Duration: Half a term

From an Inquiry-Guided Project to a CURE in General Biology: Testing Repellent Effects of Essential Oils and a Parasitoid Wasp Against Callosobruchus maculatus.
Joseph Felts, Davidson County Community College

Discipline: Life Sciences:Ecology, Life Sciences, Zoology
Core Competencies: Planning and carrying out investigations, Analyzing and interpreting data, Asking questions (for science) and defining problems (for engineering)
State: North Carolina
Target Audience: Introductory
CURE Duration: Half a term