Doxycycline Reduces Plasma VEGF-C/sVEGFR-3 and Improves Pathology in Lymphatic Filariasis

Alexander Yaw Debrah, Sabine Mand, Sabine Specht, Yeboah Marfo-Debrekyei, Linda Batsa, Kenneth Pfarr, John Larbi, Bernard Lawson, Mark Taylor, Ohene Adjei, Achim Hoerauf, PLoS Pathogens

According to this PLoS Pathogens paper, doxycycline is able to kill adult worms responsible for lymphatic filariasis, thus improving lymphatic vessel dilation and significantly ameliorating the conditions of lymphedema patients. The paper describes the specific role of Wolbachia in this disease and presents results from a placebo-controlled, double-blind study in Ghana.

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Subject: Biology, Microbiology, Microbiology:Microbiology and Health, Biology:Ecology:Symbiotic Relations
Resource Type: Scientific Resources:Research Results
Grade Level: Graduate/Professional, College Lower (13-14), College Upper (15-16)