Koki Horikoshi, Japan Marine Science and Technology Center
This 16-page in-depth review article details the biotechnological applications of alkaliphiles. It begins by discussing the definition and history of alkaliphiles, and then analyzes their distribution and isolation. The article also reviews special physiological features of alkaliphiles, physical maps of chromosomal DNAs of alkaliphilic Bacillus strains, alkaline enzymes, metabolites produced by alkaliphiles, and the future of alkaliphiles.