This eMedicine Clinical Knowledge Base webpage features information about shellfish toxicity for physicians and other healthcare professionals. Highlighting the four distinct shellfish poisoning syndromes - Paralytic shellfish poisoning (PSP), Neurologic shellfish poisoning (NSP), Diarrhetic shellfish poisoning (DSP), and Amnesic shellfish poisoning (ASP) – this webpage discusses background, pathophysiology, frequency, mortality/morbidity, age, and clinical descriptions. It also takes a deeper look at differentials, laboratory workup, treatment, medication, follow-up, medical/legal pitfalls, special concerns, and a bibliography.